Bioaccessibility of endocrine disrupting chemicals on house dust from home environment

Åsa Gustafsson

The bad quality of the indoor air have raised concerns regarding linking to the increasing prevalence of common diseases; such as cancer, diabetes, infertility etc. Many of the interiors in homes, like furniture’s, constructions, toys etc. contains synthetic chemicals, added to achieve better properties of the interior.

For example there are flame retardants and plasticizers. Some of those synthetic chemicals have a similar structure as our bodies own hormones. Therefore an exposure to these synthetic chemicals may interact with this very sophisticated endocrine system.

Many of those synthetic chemicals are volatile and end up in the indoor air. This phenomenon is dependent on the chemical and physical properties of the chemical. A lipophilic property of a chemical will adhere to small house dust particles that are floating in the indoor air. Those small house dust particles will enter the lung during inhalation. The airways have developed refined systems to handle intruders like particles, bacteria, virus etc. that are present in the air during inhalation.

The aim with this project is to understand the “destiny” for endocrine disrupting chemicals when inhaled to the lungs.

The BIG question is: What happens to these chemicals after we inhale them? Do they stick to the pollution particles or do they detach from them? Do they accumulate within the lung? Are they distributed in the blood to different organs within the body?

This project might help to answer some of these questions.