Swetox Södertälje: publikationer som genomgått peer review sedan 2014 och framåt. Klicka på länkarna för att läsa hela artiklarna.

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Ahlberg E, Carlsson L, Boyer S. (2014).  Computational derivation of structural alerts from large toxicology data sets.  Journal of Chemical Information and Modeling 54(10):2945-2952.

Annys E, Billington R, Clayton R, Bremm KD, Graziano M, McKelvie J, Ragan I, Schwarz M, van der Laan JW, Wood C, Öberg M, Wester P, Woodward KN. (2014). Advancing the 3Rs in regulatory toxicology – Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union Regul Toxicol Pharmacol, 69: 234-242.

Bogdanska J, Sundstrom M, Bergstrom U, Borg D, Abedi-Valugerdi M, Bergman A, DePierre J, Nobel, S (2014). Tissue distribution of S-35-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1-5 days. Chemosphere, 98, 28-36; DOI: 10.1016/j.chemosphere.2013.09.062

Eklund M, Norinder U, Boyer S and Carlsson L. (2014). Choosing Feature Selection and Learning Algorithms in QSAR. Journal of Chemical Information and Modeling, 54 (3), pp 837–843

Engdahl JN, Bignert A, Jones B, Athanassiadis I, Bergman Å, Weiss JM (2017) Cats’ Internal Exposure to Selected Brominated Flame Retardants and Organochlorines Correlated to House Dust and Cat Food. Enviromental Science & Technology, 51(5):3012-3020. DOI: 10.1021/acs.est.6b05025

Fries GR, Vasconcelos-Moreno MP, Gubert C, Tietböhl Martins Quadros dos Santos B, Sartori J, Eisele B, Ferrari P, Fijtman A, Rüegg J, Gassen NC, Kapczinski F, Rein T, Kauer-Sant’Anna M, (2014), The role of FKBP51 in the HPA axis dysfunction in patients with bipolar disorder and their siblings International Journal of Neuropsychopharmacology, Oct 31;18(1)

Fång J, Nyberg E, Winnberg U, Bignert A, Bergman Å. (2015). Spatial and temporal trends of the Stockholm Convention POPs in mothers’ milk – a global review. Environ Sci Pollut Res Int. 22, 8989–9041

Ghatan PH, Marcusson-Ståhl M, Matura M, Björkheden C, Lundborg P, Cederbrant K. (2014). Sensitization to omeprazole in the occupational setting. Contact Dermatitis.;71(6):371-5.

Granath, B. Holgersson, J. Cederbrant, K. Brenden, N. A (2014). Comparison of the humoral immune response induced by a recombinant human protein in wild type mice and in transgenic mice expressing the protein. Br J Pharm Res.;4(21):2511-24.

Hasselgren C, Muthas D, Ahlberg E, Andersson S, Carlsson L, Noeske T, Stålring J, and Boyer S. In Bajorath J, (Ed) (2014). Chemoinformatics and Beyond: Moving from Simple Models to Complex Relationships in Pharmaceutical Computational Toxicology. Chemoinformatics for Drug Discovery, Wiley & Sons.

Karpyak VM, Biernacka JM, Geske JR, Jenkins GD, Cunningham JM, Rüegg J, Kononenko O, Leontovich AA, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Skime MK, Frank J, Nöthen MM, Rietschel M, Kiefer F, Mann KF, Weinshilboum RM, Frye MA, Choi DS. (2014). Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosat. Translational Psychiatry, Oct 7;4:e462

Krais, A.M.; Wortmann, L.; Hermanns, L.; Feliu, N.; Vahter, M.; Stucky, S.; Mathur, S.; Fadeel, B.: »Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum«, Nanomedicine, 2014, 10, 7, 1421 – 1431

Legradi J, Dahlberg AK, Cenijn P, Marsh G, Asplund L, Bergman A, Legler J (2014). Disruption of oxidative phosphorylation (OXPHOS) by hydroxylated polybrominated diphenyl ethers (OH-PBDEs) present in the marine environment. Environmental Science and Technology, 48(24), 14703-11. doi: 10.1021/es5039744. Epub 2014 Nov 25.

Ringblom J, Johanson G, Öberg M, (2014) Current modeling practice may lead to falsely high benchmark dose estimates,  Regulatory Toxicology and Pharmacology 69:171-177

Norinder U, Carlsson L, Boyer S, Eklund M. (2014). Introducing Conformal Prediction in Predictive Modeling. A Transparent and Flexible Alternative To Applicability Domain Determination J Chem Inf Model. 54: 1596-1603

Sébillot A, Damdimopoulou P, Ogino Y, Spirhanzlova P, Miyagawa S, Du Pasquier D, Mouatassim N, Iguchi T, Lemkine GF, Demeneix BA, Tindall AJ. (2014) Rapid fluorescent detection of (anti)androgens with spiggin-gfp medaka. Environ Sci Technol. Sep 16;48(18):10919-28. doi: 10.1021/es5030977

Rodin S, Antonsson L, Niaudet C, Simonson OE, Salmela E, Hansson EM, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson AS, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjöld M, Grinnemo KH, Kere J, Betsholtz C, Hovatta O, Tryggvason K. (2014) Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun.;5:3195. doi: 10.1038/ncomms4195.

Sjogren AK, Liljevald M, Glinghammar B, Sagemark J, Li XQ, Jonebring A, Cotgreave I, Brolén G, Andersson T. (2014). Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes. Arch. Toxicol. 88: 1427-1437

Strid A, Smedje G, Athanassiadis I, Lindgren T, Lundgren H, Jakobsson K, Bergman A (2014). Brominated flame retardant exposure of aircraft personnel. Chemosphere, 116, 83-90. Special Issue: SI, DOI: 10.1016/j.chemosphere.2014.03.073

Toplak M, Močnik R, Polajnar M, Bosnić Z, Carlsson L, Hasselgren C, Demšar J, Boyer S, Zupan B and Stålring J. Assessment of Machine Learning Reliability Methods for Quantifying the Applicability Domain of QSAR Regression Models (2014). Journal of Chemical Information and Modeling 54(2), pp 431–441

van Wendel de Joode B, María Mora A, Córdoba L, Cano C, Quesada R, Faniband M, Wesseling C, Ruepert C, Öberg M, Eskenazi B, Mergler D, Lindh C, (2014) Aerial application of mancozeb is associated with elevated urinary ethylenethiourea (ETU) concentrations in pregnant women: the Infant Environmental Health Study (ISA), Environmetal Health Perspectives 122:1321-1328

Wu S, Johansson J, Damdimopoulou P, Shahsavani M, Falk A, Hovatta O, Rising A. (2014) Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells. Biomaterials. Oct;35(30):8496-502. doi: 10.1016/j.biomaterials.2014.06.039.

Yin G, Asplund L, Qiu Y, Zhou Y, Wang H, Yao Z, Jiang J, Bergman A (2014). Chlorinated and brominated organic pollutants in shellfish from the Yellow Sea and East China Sea. Environmental Science and Pollution Research International, 22, 1713-22. Ahlberg E, Carlsson L, and Boyer S. Computational derivation of structural alerts from large toxicology databases (2014). Journal of Chemical Information and Modeling 54 (10), pp 2945–2952

Zoeller RT, Bergman Å, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari J, Vandenberg LN (2014). A path forward in the debate over health impacts of endocrine disrupting chemicals. Health,13(1):118.



Al-Anati L, Viluksela M, Strid A, Bergman A, Andersson PL, Stenius U, Hogberg J, (2015). Hydroxyl metabolite of PCB 180 induces DNA damage signaling and enhances the DNA damaging effect of benzo[a]pyrene. Chemico-Biological Interactions, 239, 164-173

Ali I, Damdimopoulou P, Stenius U, Halldin K. (2015) Cadmium at nanomolar concentrations activates Raf-MEK-ERK1/2 MAPKs signaling via EGFR in human cancer cell lines. Chem Biol Interact.  Apr 25;231:44-52. doi: 10.1016/j.cbi.2015.02.014

Arlt, VA, Krais, AM.; Godschalk, RW. Riffo-Vasquez, Y, Mrizova, I, Roufosse, CA, Corbin, C, Quan, S, Frei, E, Stiborova, M, van Schooten, F-J, Phillips, D-H, Spina, D, (2015). Pulmonary inflammation impacts on CYP1A1-mediated respiratory tract DNA damage induced by the carcinogenic air pollutant benzo[a]pyrene, Journal of Toxicological Sciences. 146(2): 213–225.

Badolo, Lassina; Jensen, Bente; Saell, Carolina; Norinder, Ulf; Kallunki, Pekka; Montanari, Dino. Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture (2015). Xenobiotica, 45(2), 177-187

Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, van Thriel C, Whelan M, Fritsche E. Putative adverse outcome pathways relevant to neurotoxicity (2015). Crit Rev Toxicol., Jan;45(1):83-91

Bergman Å, Becher G, Blumberg B, Bjerregaard P, Bornman R, Brandt I, Casey SC, Frouin H, Giudice LC, Heindel JJ, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Lind PM, Muir D, Ochieng R, Ropstad E, Ross PS, Skakkebaek NE, Toppari J, Vandenberg LN, Woodruff TJ, Zoeller RT (2015). Manufacturing doubt about endocrine disrupter science – A rebuttal of industry-sponsored critical comments on the UNEP/WHO report ”State of the Science of Endocrine Disrupting Chemicals 2012”. Regul Toxicol Pharmacol., 73(3), 1007-17. doi: 10.1016/j.yrtph.2015.07.026. Epub 2015 Jul 31.

Bood JR, Sundblad BM, Delin I, Sjodin MOD, Larsson K, Anderson SD, et al. Urinary excretion of lipid mediators in response to repeated eucapnic voluntary hyperpnea in asthmatic subjects (2015) Journal of Applied Physiology, 119(3):272-9.

Checa A, Holm T, Sjodin MOD, Reinke SN, Alm J, Scheynius A, et al. Lipid mediator profile in vernix caseosa reflects skin barrier development (2015). Scientific Reports, 5

Dahlberg AK, Lindberg Chen V, Larsson K, Bergman Å, Asplund L (2015). Hydroxylated and methoxylated polybrominated diphenyl ethers in long-tailed ducks (Clangula hyemalis) and their main food, Baltic blue mussels (Mytilus trossulus × Mytilus edulis). Chemosphere. 2016 Feb, 144, 1475-83. doi: 10.1016/j.chemosphere.2015.10.012. Epub 2015 Oct 23.

Diamond ML, de Wit CA, Molander S, Scheringer M, Backhaus T, Lohmann R, Arvidsson R, Bergman Å, Hauschild M, Holoubek I, Persson L, Suzuki N, Vighi M, Zetzsch C (2015). Exploring the planetary boundary for chemical pollution. Environ Int., 78, 8-15. doi: 10.1016/j.envint.2015.02.001. Epub 2015 Feb 10. Review.

Gocht T, Berggren E, Ahr HJ, Cotgreave I, Cronin MTD, Daston G, Hardy B, Heinzle E, Hescheler J, Knight DJ, Mahony C, Peschanski M, Schwarz M, Thomas RS, Verfaillie C, White A and Whelan M. (2015). The SEURAT-1 approach towards animal free human safety assessment ALTEX (32)1: 9-24

Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, Duffel MW, Bergman Å, Robertson LW (2015). Crit Rev Toxicol. 45(3), 245-72. doi: 10.3109/10408444.2014.999365. Epub 2015 Jan 28.

Heacock M, Kelly CB, Asante KA, Birnbaum LS, Bergman AL, Bruné MN, Buka I, Carpenter DO, Chen A, Huo X, Kamel M, Landrigan PJ, Magalini F, Diaz-Barriga F, Neira M, Omar M, Pascale A, Ruchirawat M, Sly L, Sly PD, Van den Berg M, Suk WA (2015). (2015) E-Waste and Harm to Vulnerable Populations: A Growing Global Problem. Environ Health Perspect. Sep 29.

Herlin M,  Öberg M, Ringblom J, Joseph B, Korkalainen M, Vilukselad M, Heimeier RA and Håkansson H. (2015). Inhibitory effects on osteoblast differentiation in vitro by the polychlorinated biphenyl mixture Aroclor 1254 are mainly associated with the dioxin-like constituents
Toxicol in vitro (2015) 29:876-883

Huerta-García E, Márquez-Ramíreza SG, del Pilar Ramos-Godinez M, López-Saavedrad A, Herrerad LA, Parraf A, Alfaro-Moreno E, Gómezi EO, López-Marurea R. (2015). Internalization of titanium dioxide nanoparticles by glial cells is given at short times and is mainly mediated by actin reorganization-dependent endocytosis. NeuroToxicology 51, 27-37.

Kitraki E, Nalvarte I, Alavian Ghavanini A, Rüegg J. Developmental Exposure to Bisphenol A Alters Expression and DNA Methylation of Fkbp5, an Important Regulator of the Stress Response (2015). Molecular and Cellular Endocrinology, Dec 5;417:191-9

Krais, AM, Mühlbauer, K, Kucab, JE, Chinbuah, H, Cornelius, MG, Phillips, DH, Hollstein, M, Arlt, VM, Schmeiser, H. (2015) Metabolic activation of environmental carcinogens in murine embryonic stem cells and murine embryonic fibroblasts derived from the p53 Platform mouse (PLF mouse), Toxicology In Vitro, 29(1), 2015, 34–43

Nalvarte I, Damdimopoulos AE, Rüegg J, Spyrou G. The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesion (2015). Bioscience Reports, Oct 13;35(6)

Norinder U, Carlsson L, Boyer S, Eklund M Introducing conformal prediction in predictive modeling for regulatory purposes. A transparent and flexible alternative to applicability domain determination (2015). Regul Toxicol Pharmacol. 71:279–284

Norrgran J, Jones B, Bignert A, Athanassiadis I, Bergman Å (2015). Higher PBDE Serum Concentrations May Be Associated with Feline Hyperthyroidism in Swedish Cats. Environ Sci Technol 49(8), 5107-14.

Törnqvist E, Annas A, Granath B, Jalkesten E, Cotgreave I, Öberg M. Strategic focus on 3R principles reveals major reductions in the use of animals in pharmaceutical toxicity testing (2015). PLoS ONE 9(7): e101638

Ulhaq M, Sundström M, Larsson P, Gabrielsson J, Bergman Å, Norrgren L, Örn S (2015). Tissue uptake, distribution and elimination of 14C-PFOA in zebrafish (Danio rerio). Aquatic Toxicology, 148–157

Vicente-Carrillo A, Edebert I, Garside H, Cotgreave I, Rigler R, Loitto V, Magnusson KE, Rodríguez-Martínez H. Boar spermatozoa successfully predict mitochondrial modes of toxicity: Implications for drug toxicity testing and the 3R principles (2015). Toxicology in Vitro 29 582–591

Zhang H, Panula S, Petropoulos S, Edsgärd D, Busayavalasa K, Liu L, Li X, Risal S, Shen Y, Shao J, Liu M, Li S, Zhang D, Zhang X, Gerner RR, Sheikhi M, Damdimopoulou P, Sandberg R, Douagi I, Gustafsson JÅ, Liu L, Lanner F, Hovatta O, Liu K. (2015) Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells. Nat Med. Oct;21(10):1116-8. doi: 10.1038/nm.3775

Zhou Y, Yin G, Asplund L, Qiu Y, Bignert A, Zhu Z, Zhao J, Bergman Å (2015). A novel pollution pattern: Highly chlorinated biphenyls retained in Black-crowned night heron (Nycticorax nycticorax) and Whiskered tern (Chlidonias hybrida) from the Yangtze River Delta. Chemosphere, 2015 Dec 15, S0045-6535(15)30443-4. doi: 10.1016/j.chemosphere.2015.11.112. [Epub ahead of print]


Ali I, Hurmerinta T, Nurmi T, Berglund M, Rüegg J, Poutanen M, Halldin K, Mäkelä S, Damdimopoulou P. (2016) From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo. Toxicol Lett.  Jun 24;253:27-35. doi: 10.1016/j.toxlet.2016.04.020.

Attoff K, Kertika D, Lundqvist J, Oredsson S, Forsby A. Acrylamide affects proliferation and differentiation of the neural progenitor cell line C17.2 and the neuroblastoma cell line SH-SY5Y. Toxicol In Vitro. (2016) Sep;35:100-11. doi: 10.1016/j.tiv.2016.05.014. Epub 2016 May 27.

Balgoma D, Yang M, Sjödin MOD, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle D, Dahlén SE, Dahlén B, Sköld M, Wheelock Å, Wheelock C (2016). Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD. European Respiratory Journal 47(6) 1635-1644. DOI: 10.1183/13993003.01485-2015

Bourguignon J-P, Slama R, Bergman Å, Demeneix B, Ivell R, Kortenkamp A, Panzica G, Trasande L, Zoeller RT (2016). Science-based regulation of endocrine disrupting chemicals in Europe: which approach? Lancet Diabetes Endocrinol (2016) Online June 13, 2016; doi: 10.1016/S2213-8587(16)30121-8

Damdimopoulou P, Rodin S, Stenfelt S, Antonsson L, Tryggvason K, Hovatta O. (2016) Human embryonic stem cells. Best Pract Res Clin Obstet Gynaecol.  Feb;31:2-12. doi: 10.1016/j.bpobgyn.2015.08.010.

Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preissinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T. Chaperoning epigenetics: FK506 Binding Protein 51 decreases DNA Methyltransferase 1 phosphorylation and activity. Science Signaling, Nov 24;8(404):ra119

Gassmann K, Schreiber T, Dingemans MML, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman A, Westerink RHS, Rose CR, Fritsche E (2014). BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Archives of toxicology, 88 (8), 1537-1548. DOI: 10.1007/s00204-014-1217-7

Johansson M, Johanson G, Öberg M, Schenk L. (2016) Does industry take the susceptible subpopulation of asthmatic individuals into consideration when setting Derived No-Effect Levels (DNELs)? J Appl Toxicol 1379–1391 (Published online: DOI 10.1002/jat.3352)

Johansson M, Johanson G, Öberg M. (2016) Evaluation of the experimental basis for assessment factors to protect individuals with asthma from health effects during short-term exposure to airborne chemicals. Crit Rev Toxicol. 46: 241-260

Juma AR, Damdimopoulou PE, Grommen SV, Van de Ven WJ, De Groef B. (2016) Emerging role of PLAG1 as a regulator of growth and reproduction. J Endocrinol. Feb;228(2):R45-56. doi: 10.1530/JOE-15-0449

Kemiläinen H, Adam M, Mäki-Jouppila J, Damdimopoulou P, Damdimopoulos AE, Kere J, Hovatta O, Laajala TD, Aittokallio T, Adamski J, Ryberg H, Ohlsson C, Strauss L, Poutanen M. (2016) The hydroxysteroid (17β) dehydrogenase family gene HSD17B12 is involved in the prostaglandin synthesis pathway, the ovarian function, and regulation of fertility. Endocrinology. Aug 4:en20161252.

Kitraki e, Nalvarte I, Alavian-Ghavanini A, Rüegg J. Effects of pre- and post-natal exposure to bisphenol A on the stress system (2016). Endocrine Disruptors, 4:1, e1184775

Kortenkamp A, Bourguignon JP, Slama R, Bergman A, Demeneix B, Ivell R, Panzica G, Trasande L, Zoeller RT (2016). EU regulation of endocrine disruptors: a missed opportunity. Lancet Diabetes & Endocrinology, 4(8):649-650. doi: 10.1016/S2213-8587(16)30151-6

Krais, A. M, Speksnijder, W, Melis, J. P. M, Singh, R, Caldwell, A, Gamboa da Costa, G, Luijten, M, Phillips, DH, Arlt, VM. (2016) Metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and DNA adduct formation depends on p53: studies in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice«, Int J Cancer 138(4), 976-982

Krais, A. M.; Speksnijder, E. N.; Melis, J. P.M.; Radek, I.; Moserova, M.; Godschalk, R. W.; van Schooten, F.J.; Seidel, A.; Kopka, K.; Schmeiser, H. H.; Stiborova, M.; Phillips, D. H.; Luijten, M.; Arlt, V.M.: (2016) The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice«, Archives of Toxicology 90 (4), 839–835.

Lind L, Lind M, Lejonklou M, Dunder L, Bergman Å, Guerrero-Bosagna C, Lampa E, Kyu Lee H, Legler J, Nadal A,  Kim Pak Y, Phipps R, Vandenberg L, Zalko D, Ågerstrand M, Öberg M, Blumberg B, Heindel J, Birnbaum L. (2016) Uppsala Consensus Statement on Environmental Contaminants and the global obesity epidemic. Environmental Health Perspectives 124(5): A81–A83

Lindsjö J, Fahlman Å, Törnqvist E. (2016). Animal welfare from mouse to moose – implementing the principles of the 3Rs in wildlife research Journal of Wildlife Diseases, 52(2) Supplement, pp. S65–S77

Liu Y, Duong W, Krawczyk C, Bretschneider N, Borbély G, Varshney M, Zinser C, Schär P, Rüegg J. (2016). Oestrogen receptor beta regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase Epigenetics and Chromatin, Feb 16;9:7

Meng XZ, Venkatesan AK, Ni YL, Steele JC, Wu LL, Bignert A, Bergman Å, Halden RU (2016) Organic Contaminants in Chinese Sewage Sludge: A Meta-Analysis of the Literature of the Past 30 Years. Environ Sci Technol. Jun 7;50(11):5454-66. doi: 10.1021/acs.est.5b05583. Epub 2016 May 13.

Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, Göpfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, Uhlén M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I.Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.Liver Int. 2016 May 25. doi: 10.1111/liv.13174. [Epub ahead of print]

Norinder, U.; Rybacka, A.; Andersson, P. L. (2016). Conformal prediction to define applicability domain – A case study on predicting ER and AR binding, SAR and QSAR in Environmental Research 27(4), 303-316.

Norinder, U, Boyer, S (2016). Conformal Prediction Classification of a Large Data Set of Environmental Chemicals from ToxCast and Tox21 Estrogen Receptor Assays, Chemical Research in Toxicology 29(6), 1003-1010.

Rueda-Romero C, Hernández-Pérez G, Ramos-Godínez P, Vázquez-López I, Quintana-Belmares RO, Huerta-García E, Stepien E, López-Marure R, Montiel-Dávalos A, Alfaro-Moreno E. Titanium dioxide nanoparticles induce the expression of early and late receptors for adhesion molecules on monocytes. Particle and Fibre Toxicology (Accepted for publication)

Schmidt BZ, Lehmann M, Gutbier S, Nembo E, Noel S, Smirnova L, Forsby A, Hescheler J, Avci HX, Hartung T, Leist M, Kobolák J, Dinnyés A. In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities. Arch Toxicol. (2016) Aug 4. [Epub ahead of print] Review.

Smirnova A, Wincent E, Vikström Bergander L, Alsberg T, Bergman J, Rannug A, Rannug U. Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ. Chem Res Toxicol. 2016 Jan 19;29(1):75-86. doi: 10.1021/acs.chemrestox.5b00416

Thulin P, Bamberg K, Buler M, Dahl B, Glinghammar B. (2016) The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels. Int J Mol Med. Sep;38(3):961-8.

Vandenberg LN, Agerstrand M, Beronius A, Beausoleil C, Bergman A, Bero LA, Bornehag CG, Boyer CS, Cooper GS, Cotgreave I, Gee D, Grandjean P, Guyton KZ, Hass U, Heindel JJ, Jobling S, Kidd KA, Kortenkamp A, Macleod MR, Martin OV, Norinder U, Scheringer M, Thayer KA, Toppari J, Whaley P, Woodruff TJ, Ruden C (2016). A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. Environmental Health, 15. doi: 10.1186/s12940-016-0156-6

Wincent E, Florane Le Bihanic and Kristian Dreij. Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons. Toxicol. Res., 2016, 5, 788-799. doi: 10.1039/C6TX00004E

Wincent E, Kubota A, Timme-Laragy A, Jönsson ME, Hahn ME, Stegeman JJ. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol. 2016 Jun 15;110-111:117-29. doi: 10.1016/j.bcp.2016.04.012

Wohak, L.; Krais, A.M.; Kucab, J.; Seidel, A.; Phillips, D.H.; Arlt, V.M.: »Impact of TP53 status on the metabolic activation of environmental carcinogens in HCT116 cells«, Archives of Toxicology, 2016, 90, 2, 291 – 304

Zhou Y, Asplund L, Yin G, Athanassiadis I, Wideqvist U, Bignert A, Qiu Y, Zhu Z, Zhao J, Bergman Å. (2016). Extensive organohalogen contamination in wildlife from a site in the Yangtze River Delta. Sci Total Environ. 554-555, 320-8.


Ahlberg E, Winiwarter S, Boström H, Linusson H, Löfström T, Norinder U, Johansson U, Engkvist O, Hammar O, Bendtsen C, Carlsson L. 2017. Using Conformal Prediction to Prioritize Compound Synthesis in Drug Discovery, PMLR 60:174-184.

Alavian-Ghavanini A, Rüegg J. Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: from Mechanisms to Novel Test Methods. Basic & Clinical Pharmacology & Toxicology, 2017. In press. 10.1111/bcpt.12878

Arlt, V.M.; Meinl, W.; Florian, S.; Nagy, E.; Bartac, F.; Thomann, M.; Mrizovac, I.; Krais, A.M.; … Stiborova, M.; Schmeiser, H.H.: »Impact of genetic modulation of the SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone«, Archives of Toxicology, 2017, 91, 4, 1957-1975

Barde S,  Ruegg J,  Prud’homme J,  Ekstrom TJ,  Palkovits M,  Turecki G,  Bagdy G,  Ihnatko R,  Theodorsson E,  Juhasz G,  Diaz-Heijtz R,  Mechawar N,  Hokfelt TGM. Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016 113;52 E8472-E8481. PMID: 27940914

Hamm J, Sullivan K, Clippinger AJ, Strickland J, Bell S, Bhhatarai B, Blaauboer B, Casey W, Dorman D, Forsby A, Garcia-Reyero N, Gehen S, Graepel R, Hotchkiss J, Lowit A, Matheson J, Reaves E, Scarano L, Sprankle C, Tunkel J, Wilson D, Xia M, Zhu H, Allen D. (2017). Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing. Toxicol In Vitro. 41:245-259. doi: 10.1016/j.tiv.2017.01.004.

Jacobs MN, Marczylo EL, Guerrero-Bosagna C, Rüegg J. Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals. Annu. Rev. Environ. Resour. 2017. 42:23.1—23.56.

Johansson M, Gustafsson Å, Johanson G, Öberg M. (2017). Comparison of airway response in naïve and ovalbumin-sensitized mice during short-term inhalation exposure to chlorine
Inhalation Toxicology 2017; 29:82-91

Juma AR, Grommen SVH, O’Bryan MK, O’Connor AE, Merriner DJ, Hall NE, Doyle SR, Damdimopoulou PE, Barriga D, Hart AH, Van de Ven WJM, De Groef B. PLAG1 deficiency impairs spermatogenesis and sperm motility in mice.  Sci Rep. 2017 Jul 13;7(1):5317. doi: 10.1038/s41598-017-05676-4.

Kalantari F, Ringblom J, Sand S, Öberg M. (2017) Influence of Distribution of Animals between Dose Groups on the Estimation of the Benchmark Dose and on Animal Distress for Quantal Responses.
Risk Analysis 2017; 37:1716-1728

Lindh, M, Karlen, A, Norinder, U. 2017. Predicting the Rate of Skin Penetration Using an Aggregated Conformal Prediction Framework, Molecular Pharmaceutics, 14(5), 1571-1576. DOI:10.1021/acs.molpharmaceut.7b00007

Linusson H, Norinder U, Boström H, Johansson U, Löfström T. 2017. On the Calibration of Aggregated Conformal Predictors, PMLR 60:154-173

Ljunggren, SA, Helmfrid, I, Norinder, U, Fredriksson, M, Wingren, G, Karlsson, H, Lindahl, M. 2017. Alterations in high-density lipoprotein proteome and function associated with persistent organic pollutants, Environment International, 98, 204-211. DOI:10.1016/j.envint.2016.11.008

Lundgren H, Martinsson K, Cederbrant K, Jirholt J, Mucs D, Madeyski-Bengtson K, Havarinasab S, Hultman P (2017) HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity. PLoS ONE

Lundqvist J., Svensson C., Attoff K., Forsby A. (2017) Altered mRNA Expression and Cell Membrane Potential in the Differentiated C17.2 Cell Model as Indicators of Acute Neurotoxicity. Applied In Vitro Toxicology 3(2): 154-162. (DOI: 10.1089/aivt.2016.0022).

Lupu D, Sjödin M, Varshney M, Lindberg J, Loghin F, Rüegg J. (2017) Fluoxetine modulates sex steroid levels in vitro. Clujul Med. 2017. In press. DOI: 10.15386/cjmed-868.

Müller, R., Hanson, C., Hanson, M., Penkler, M., Samaras, G., Chiapperino, L., Dupre, J., Kenney, M., Kuzawa, C., Latimer, J., Lloyd, S., Lunkes, A., MacDonald, M., Meloni, M., Nerlich, B., Panese, F., Pickersgill, M., Richardson, S., Rüegg J., Schmitz, S., Stelmach, A., and Villa P. The Biosocial Genome? Interdisciplinary Perspectives on Environmental Epigenetics, Health and Society. EMBO Reports, Science & Society section, in press.

Norinder, U, Boyer, S. 2017. Binary classification of imbalanced datasets using conformal prediction, Journal of Molecular Graphics & Modelling, 72, 256-265. DOI:10.1016/j.jmgm.2017.01.008

Norinder U, Svensson F, Afzal AM, Bender A. 2017. Maximizing Gain in HTS Screening Using Conformal Prediction, PMLR 60:103-117.

Ringblom J, Kalantari F, Johanson G, Öberg M. (2017). Influence of Distribution of Animals between Dose Groups on the Estimation of the Benchmark Dose and on Animal Distress for Continuous Effects.
(Risk Analysis, EPub ahead of print, DOI: 10.1111/risa.12929)

Ringblom J, Törnqvist E, Hansson SO, Rudén C, Öberg M, (2017) Assigning ethical weights to clinical signs observed during toxicity testing. ALTEX 34(1):148-156.

Schenk L, Feychting K, Annas A, Öberg M. (2017). Records from the Swedish Poisons Information Centre as a means for surveillance of occupational accidents and incidents with chemicals
(Accepted for publication in Safety Science)

Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B. Feedback control of AHR signalling regulates intestinal immunity. Nature. 2017 Feb 9;542(7640):242-245. doi: 10.1038/nature21080

Schmidt BZ, Lehmann M, Gutbier S, Nembo E, Noel S, Smirnova L, Forsby A, Hescheler J, Avci HX, Hartung T, Leist M, Kobolák J, Dinnyés A. (2017). In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities. Arch Toxicol., 91(1):1-33. doi: 10.1007/s00204-016-1805-9.

Sun, J, Carlsson, L, Ahlberg, E, Norinder, U, Engkvist, O, Chen, H. 2017. Applying Mondrian Cross-Conformal Prediction To Estimate Prediction Confidence on Large Imbalanced Bioactivity Data Sets, Journal of Chemical Information and Modeling, 57(7), 1591-1598. DOI:10.1021/acs.jcim.7b00159

Svensson, F, Norinder, U, Bender, A. 2017. Improving Screening Efficiency through Iterative Screening Using Docking and Conformal Prediction, Journal of Chemical Information and Modeling, 57(3), 439-444. DOI:10.1021/acs.jcim.6b00532

Svensson, F, Norinder, U, Bender, A. 2017. Modelling compound cytotoxicity using conformal prediction and PubChem HTS data, Toxicology Research (Cambridge, United Kingdom), 6(1), 73-80. DOI:10.1039/C6TX00252H

Thulin P, Hornby RJ, Auli M, Nordahl G, Antoine DJ, Starkey Lewis P, Goldring CE, Park BK, Prats N, Glinghammar B, Schuppe-Koistinen I. A longitudinalassessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat. Biomarkers. 2017 Jul;22(5):461-469.

Wu Y, Zhou YH, Qiu YL, Chen D, Zhu ZL, Zhao JF, Bergman Å (2017) Occurrence and risk assessment of trace metals and metalloids in sediments and benthic invertebrates from Dianshan Lake, China. Enviromental Science and Pollution Research, 24(17):14847-14856. DOI: 10.1007/s11356-017-9069-3

Yin G, Athanassiadis L, Bergman Å, Zhou YH, Qiu YL, Asplund L (2017) A refined method for analysis of 4,4 ‘- dicofol and 4,4 ‘- dichlorobenzophenone. Enviromental Science and Pollution Research, 24(15):13307-13314. DOI: 10.1007/s11356-017-8956-y

Yuan B, Strid A, Darnerud PO, de Wit CA, Nyström J, Bergman Å (2017). Chlorinated paraffins leaking from hand blenders can lead to significant human exposures . Environment International
Volume 109: 73–80 .

Zhou YH, Yin G, Asplund L, Stewart K, Rantakokko P, Bignert A, Ruokojarvi P, Kiviranta H, Qiu YL, Ma ZJ, Bergman Å (2017) Human exposure to PCDDs and their precursors from heron and tern eggs in the Yangtze River Delta indicate PCP origin. Environmental Pollution, 225: 184-192. DOI: 10.1016/j.envpol.2017.03.052


Feltmann K, Borroto-Escuela DO, Rüegg J, Pinton L, de Oliveira Sergio T, Narváez M, Jimenez-Beristain A, Ekström TJ, Fuxe K, Steensland P. Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. Alcohol Clin Exp Res. 2018 Feb;42(2):338-351. doi: 10.1111/acer.13568. Epub 2018 Jan 24. PMID: 29205397

Forreryd, Andy; Norinder, Ulf; Lindberg, Tim; Lindstedt, Malin, Predicting skin sensitizers with confidence – Using conformal prediction to determine, applicability domain of GARD. Toxicology In Vitro (2018), 48, 179-187, DOI:10.1016/j.tiv.2018.01.021

Gustafsson Å, Krais AM, Gorzsás A, Lundh T, Gerde P. Isolation and characterization of a respirable particle fraction from residential house-dust. Environ Res. 2018 Feb;161:284-290. doi: 10.1016/j.envres.2017.10.049. Epub 2017 Nov 21.

Huerta-García E, Zepeda-Quiroz I, Sánchez-Barrera H, Colín-Val Z, Alfaro-Moreno E, Ramos-Godinez MDP, López-Marure R.
Internalization of Titanium Dioxide Nanoparticles Is Cytotoxic for H9c2 Rat Cardiomyoblasts.
Molecules. 2018 Aug 6;23(8). pii: E1955. doi: 10.3390/molecules23081955.

Ulf Norinder, Daniel Mucs, Theodor Pipping, Anna Forsby, Creating an efficient screening model for TRPV1 agonists using conformal prediction, Computational Toxicology 6, 2018, 9-15

Quintana-Belmares RO, Krais AM, Esfahani BK, Rosas-Pérez I, Mucs D, López-Marure R, Bergman Å, Alfaro-Moreno E. Phthalate esters on urban airborne particles: Levels in PM10 and PM2.5 from Mexico City and theoretical assessment of lung exposure. Environmental Research 2018; 161: 439-445

Sanchez Garcia, Diana; Sjoedin, Marcus; Hellstrandh, Magnus; Norinder, Ulf; Nikiforova, Violetta; Lindberg, Johan; Wincent, Emma; Bergman, Aake; Cotgreave, Ian; Munic Kos, Vesna, Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) – A comparison with lysosomotropic drugs. Chemico-Biological Interactions (2018), 281, 1-10, DOI:10.1016/j.cbi.2017.12.021

Schiering C, Vonk A, Das S, Stockinger B, Wincent E. Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells. Biochem Pharmacol. 2018 Mar 1;151:47-58. doi: 10.1016/j.bcp.2018.02.031. [Epub ahead of print]

Svensson Fredrik; Afzal Avid M; Bender Andreas; Norinder Ulf;,Maximizing gain in high-throughput screening using conformal prediction, Journal of cheminformatics (2018), 10(1), 7

Wei W, Bonvallot N, Gustafsson Å, Raffy G, Glorennec P, Krais A, Ramalho O, Le Bot B, Mandin C. Bioaccessibility and bioavailability of environmental semi-volatile organic compounds via inhalation: A review of methods and models. Environ Int. 2018 Feb 12;113:202-213. doi: 10.1016/j.envint.2018.01.024. [Epub ahead of print] Review.

Weiss JM, Gustafsson Å, Gerde P, Bergman Å, Lindh CH, Krais AM. Daily intake of phthalates, MEHP, and DINCH by ingestion and inhalation. Chemosphere. 2018 May 17;208:40-49. doi: 10.1016/j.chemosphere.2018.05.094. [Epub ahead of print]