A newly formed EU-project will develop chemical risk assessment through improved understanding of the health effects of endocrine disrupting chemicals. The aim is to promote the use of safer chemicals for the next generation.
EDC-MixRisk is a four-year project financed through the EU Commission’s programme Horizon 2020, which started in the spring of 2015. It involves participation from six Swedish Swetox-universities, as well as five European and one American.
The project focuses on the effects of mixtures of endocrine disruptive chemicals (EDCs) on children. A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife.
The project will promote use of safer chemicals for the next generation. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures.
The project addresses these concerns by developing chemical risk assessment through improved understanding of the mechanisms and health effects of EDCs, in particular as mixtures. This approach involves selection, refinement and development of tools for assessment of EDC mixtures to bring current risk assessment procedures to a level where they can support risk management.
The interdisciplinary and integrated research approach includes:
- epidemiology of two child cohorts focused on three health domains (growth and metabolism, neurodevelopment, and sexual development)
- a web of experimental toxicology and molecular biology approaches to determine multiple adverse health outcomes with pathways starting at the molecular level during early life exposure to EDC mixtures
- regulatory toxicology for development of a transparent and systematic risk assessment framework. Together this interdisciplinary research, integrating epidemiologic and experimental evidence, will facilitate assessment of risk and societal impact ensuring better risk management for EDCs and their mixtures.